Nuclear chromosomal localization in human preimplantation embryos: correlation with aneuploidy and embryo morphology
نویسندگان
چکیده
منابع مشابه
Positive outcome after preimplantation diagnosis of aneuploidy in human embryos.
usromosomal abnormalities are responsible for a great deal of embryo wastage, which is reflected, at least partially, in decreased implantation and increased miscarriage in older women. To address this problem the transfer of only chromosomally normal embryos previously selected by preimplantation genetic diagnosis (PGD) has been proposed. We designed a multi-centre in-vitro fertilization (IVF)...
متن کاملThe Role of Aneuploidy Screening in Human Preimplantation Embryos
Aneuploidy can be defined as extra or missing whole chromosomes in the nucleus of a cell and occurs during cell division when chromosomes do not separate equally between the two new daughter cells (Hassold & Hunt 2001). Chromosome imbalance typically results in non-viability, manifesting as developmental arrest prior to implantation, miscarriage or stillbirth. Depending on the chromosomes invol...
متن کاملChromosomal mosaicism in human preimplantation embryos: a systematic review.
BACKGROUND Although chromosomal mosaicism in human preimplantation embryos has been described for almost two decades, its exact prevalence is still unknown. The prevalence of mosaicism is important in the context of preimplantation genetic screening in which the chromosomal status of an embryo is determined by the analysis of a single cell from that embryo. METHODS Here we report a systematic...
متن کاملAnaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos.
BACKGROUND Cleavage stage embryos as well as postimplantation embryos have been studied extensively over the years. However, our knowledge with respect to the chromosomal constitution of human embryos at the blastocyst stage is still rudimentary. METHODS In the present paper, a large series of human blastocysts was examined by means of fluorescent in situ hybridization (FISH). RESULTS It wa...
متن کاملFrequency of chromosomal aneuploidy in high quality embryos from young couples using preimplantation genetic screening
BACKGROUND Selection of the best embryo for transfer is very important in assisted reproductive technology (ART). Using morphological assessment for this selection demonstrated that the correlation between embryo morphology and implantation potential is relatively weak. On the other hand, aneuploidy is a key genetic factor that can influence human reproductive success in ART. OBJECTIVE The ai...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2004
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/deh391